Monodisperse sodium oleate coated magnetite high susceptibility nanoparticles for hyperthermia applications

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:364

Article

Araujo-Neto, R. P.¹  Silva-Freitas, E. L.¹  Carvalho, J. F.¹  Pontes, T. R. F.¹  Silva, K. L.¹  Damasceno, I. H. M.¹  Egito, E. S. T.¹  Dantas, Ana L.²  Morales, Marco A.³  Carrico, Artur S.³ 

[1] Univ Fed Rio Grande do Norte, Dept Farm, BR-59012570 Natal, RN, Brazil

[2] Univ Estado Rio Grande do Norte, Dept Fis, BR-59610210 Mossoro, RN, Brazil

[3] Univ Fed Rio Grande do Norte, Dept Fis Teor & Expt, BR-59078970 Natal, RN, Brazil

关键词: Nanoparticle;    Superparamagnetic;    Magnetite;    Sodium oleate;    Hyperthermia;   

DOI  :  10.1016/j.jmmm.2014.04.001

来源: Elsevier

【 摘 要 】

We report a simple and low cost methodology to synthesize sodium oleate coated magnetite nano particles for hyperthermia applications. The system consists of oleate coated magnetite nanoparticles with large susceptibility (1065 emu/gT), induced by the dipolar inter particle interaction, with a magnetic core diameter in the 6 nm-12 nm size range. In aqueous medium, the nanoparticles agglomerate to form a monodisperse system, exhibiting a mean hydrodynamic diameter of 60.6 nm +/- 4.1 nm, with a low average polydispersity index of 0.128 +/- 0.003, as required for intravenous applications. The system exhibits promising efficiency for magnetic hyperthermia, with a specific absorption rate of 14 Wig at a low field amplitude of 15.9 kAirn and frequency of 62 kHz. In a 50 mg/mL density in 1 mL, the temperature rises to 42.5 degrees C in 1.9 min. (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

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