Tessellated permanent magnet circuits for flow-through, open gradient separations of weakly magnetic materials

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:427

Article

Moore, Lee R.¹  Williams, P. Stephen²  Chalmers, Jeffrey J.³  Zborowski, Maciej¹ 

[1] Cleveland Clin, Dept Biomed Engn, 9500 Euclid Ave, Cleveland, OH 44195 USA

[2] Cambrian Technol Inc, Cleveland, OH USA

[3] Ohio State Univ, William G Lowrie Dept Chem & Biomed Engn, Columbus 151 W Woodruff Ave, Columbus, OH 43210 USA

关键词: Magnetic separation;    Biomagnetism;    Open-gradient magnetic separation;    Red blood cell magnetic susceptibility;   

DOI  :  10.1016/j.jmmm.2016.11.027

来源: Elsevier

【 摘 要 】

Emerging microfluidic-based cell assays favor label-free red blood cell (RBC) depletion. Magnetic separation of RBC is possible because of the paramagnetism of deoxygenated hemoglobin but the process is slow for openg-radient field configurations. In order to increase the throughput, periodic arrangements of the unit magnets were considered, consisting of commercially available Nd-Fe-B permanent magnets and soft steel flux return pieces. The magnet design is uniquely suitable for multiplexing by magnet tessellation, here meaning the tiling of the magnet assembly cross-sectional plane by periodic repetition of the magnet and the flow channel shapes. The periodic pattern of magnet magnetizations allows a reduction of the magnetic material per channel with minimal distortion of the field cylindrical symmetry inside the magnet apertures. A number of such magnet patterns are investigated for separator performance, size and economy with the goal of designing an open-gradient magnetic separator capable of reducing the RBC number concentration a hundred-fold in 1 mL whole blood per hour.

【 授权许可】

Free