Depth limitations for in vivo magnetic nanoparticle detection with a compact handheld device

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:380

Article; Proceedings Paper

Visscher, Martijn¹  Waanders, Sebastiaan¹  Pouw, Joost¹  ten Haken, Bennie¹ 

[1] Univ Twente, MIRA, Inst Biomed Technol & Tech Med, NL-7522 NB Enschede, Netherlands

关键词: Nonlinear susceptibility;    Magnetic nanoparticle;    Biomedical sensing;    Diamagnetism of tissue;    In vivo detection;    Intraoperative sentinel lymph node detection;   

DOI  :  10.1016/j.jmmm.2014.09.076

来源: Elsevier

【 摘 要 】

The increasing interest for local detection of magnetic nanoparticles (MNPs) during clinical interventions requires the development of suitable probes that unambiguously detect the MNPs at a depth of several centimeters in the body. The present study quantitatively evaluates the limitations of a conventional magnetometry method using a sinusoidal alternating field. This method is limited by the variability of the magnetic susceptibility of the surrounding diamagnetic tissue. Two different sensors are evaluated in a theoretical model of MNP detection in a tissue volume. For a coil that completely encloses the sample volume, the MNPs can be detected if the total mass contributing to the signal is larger than 4.1 x 10(-7) times the tissue mass. For a handheld surface coil, intended to search for the MNPs in a larger tissue volume, an amount of 1 mu g of iron oxide cannot be detected by sensors with a diameter larger than 15 mm. To detect a spot with MNPs at 5 cm depth in tissue, it should contain at least 325 mu g iron oxide. Therefore, for high-sensitive clinical MNP detection in surgical interventions, techniques with increased specificity for the nonlinear magnetic properties of MNPs are indispensable. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

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