JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 卷:380 |
Magnetic microgels for drug targeting applications: Physical-chemical properties and cytotoxicity evaluation | |
Article; Proceedings Paper | |
Turcu, Rodica1  Craciunescu, Izabell1  Garamus, Vasil M.2  Janko, Christina3  Lyer, Stefan3  Tietze, Rainer3  Alexiou, Christoph3  Vekas, Ladislau4  | |
[1] Natl Inst Res & Dev Isotop & Mol Technol, Cluj Napoca 400293, Romania | |
[2] Zentrum Mat & Kustenforschung GmbH, Helmholtz Zentrum Geesthacht, D-21502 Geesthacht, Germany | |
[3] Univ Hosp Erlangen, Else Kroner Fresenius Stiftung Professorship, SEON, ENT Dept, Erlangen, Germany | |
[4] Romanian Acad, Timisoara Branch, CFATR, Lab Magnet Fluids, Timisoara 300223, Romania | |
关键词: Magnetic microgel; Iron oxide nanoparticles; Cytotoxicity; Targeted drug delivery; X-ray Photoelectron Spectroscopy; Small Angle X-ray Scattering; | |
DOI : 10.1016/j.jmmm.2014.08.041 | |
来源: Elsevier | |
【 摘 要 】
Magnetoresponsive microgels with high saturation magnetization values have been obtained by a strategy based on the miniemulsion method using high colloidal stability organic carrier ferrofluid as primary material. Hydrophobic nanoparticles Fe3O4/oleic acid are densely packed into well-defined spherical nanoparricle clusters coated with polymers with sizes in the range 40-350 nm. Physical chemical characteristics of magnetic microgels were investigated by TEM. SAXS, XPS and VSM measurements with the focus on the structure properties relationship. The impact of magnetic microgels loaded with anticancer drug miLoxantrone (MTO) on the non adherent human T cell leukemia line Jurkar was investigated in rnultiparameter flow cytometry. We showed that both MTO and rnicrogel-loaded MTO penetrate into cells and both induce apoptosis and later secondary necrosis in a time and dose dependent manner. In contrast, microgels without MTO are not cytotoxic in the corresponding concentrations. Our results show that MTO-loaded microgels are promising structures for application in magnetic drug targeting.(C) 2014 Elsevier B.V. All rights reserved.
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