Water dispersible CoFe2O4 nanoparticles with improved colloidal stability for biomedical applications

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:404

Article

Munjal, Sandeep¹  Khare, Neeraj¹  Nehate, Chetan²  Koul, Veena² 

[1] Indian Inst Technol Delhi, Dept Phys, New Delhi 110016, India

[2] Indian Inst Technol Delhi, Ctr Biomed Engn, New Delhi 110016, India

关键词: CoFe2O4;    Biomedical applications;    Ligand exchange;    Superparamagnetism;    Nanoparticles;   

DOI  :  10.1016/j.jmmm.2015.12.017

来源: Elsevier

【 摘 要 】

Single phase cobalt ferrite (CoFe2O4, CFO) nanoparticles of a controlled size (similar to 6 nm) exhibiting superparamagnetic properties have been synthesized by hydrothermal technique using oleic acid (OA) as surfactant. The oleic acid coated CFO nanoparticles are stable in non-polar organic media, such as hexane but are not well dispersible in water. The surface of these nanoparticles has been further modified by citric acid using ligand exchange process, which makes CFO nanoparticles more stable colloidal solution in water. Citric acid coated CFO nanoparticles exhibits high dispersibility in water, high zeta potential, very low coercivity and moderate saturation magnetization. Biocompatibility of these CFO nanoparticles is demonstrated through cytotoxicity test in L929 cell line. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

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