Simultaneous Magnetic Particle Imaging and Navigation of large superparamagnetic nanoparticles in bifurcation flow experiments

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:498

Article

Griese, Florian^1,2  Knopp, Tobias^1,2  Gruettner, Cordula⁴  Thieben, Florian^1,2  Mueller, Knut⁴  Loges, Sonja^5,6  Ludewig, Peter³  Gdaniec, Nadine^1,2 

[1] Univ Med Ctr Hamburg Eppendorf, Sect Biomed Imaging, Hamburg, Germany

[2] Hamburg Univ Technol, Inst Biomed Imaging, Hamburg, Germany

[3] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, Hamburg, Germany

[4] Micromod Partikeltechnol GmbH, Rostock, Germany

[5] Univ Med Ctr Hamburg Eppendorf, Dept Oncol Hematol & Bone Marrow Transplantat, Hubertus Wald Tumorzentrum, Sect Pneumol,Hubertus Wald Comprehens Canc Ctr Ha, Hamburg, Germany

[6] Univ Med Ctr Hamburg Eppendorf, Dept Tumor Biol, Ctr Med Expt, Hamburg, Germany

关键词: Magnetic Particle Imaging;    MPI;    Magnetic Particle Navigation MPN;    Targeted drug delivery;    Beads;    Micron-sized particles;    Quasi-simultaneously;    Superparamagnetic;    Bifurcation;    Stenosis;    Flow velocity;    Magnetic particles;   

DOI  :  10.1016/j.jmmm.2019.166206

来源: Elsevier

【 摘 要 】

Magnetic Particle Imaging (MPI) has been successfully used to visualize the distribution of superparamagnetic nanoparticles within 3D volumes with high sensitivity in real time. Since the magnetic field topology of MPI scanners is well suited for applying magnetic forces on particles and micron-sized ferromagnetic devices, MPI has been recently used to navigate micron-sized particles and micron-sized swimmers. In this work, we analyze the magnetophoretic mobility and the imaging performance of two different particle types for Magnetic Particle Imaging/Navigation (MPIN). MPIN constantly switches between imaging and magnetic modes, enabling quasi-simultaneous navigation and imaging of particles. We determine the limiting flow velocity to be 8.18 mL s(-1) using a flow bifurcation experiment, that allows all particles to flow only through one branch of the bifurcation. Furthermore, we have succeeded in navigating the particles through the branch of a bifurcation phantom narrowed by either 60% or 100% stenosis, while imaging their accumulation on the stenosis. The particles in combination with therapeutic substances have a high potential for targeted drug delivery and could help to reduce the dose and improve the efficacy of the drug, e.g. for specific tumor therapy and ischemic stroke therapy.

【 授权许可】

Free