Calculation of nanoparticle capture efficiency in magnetic drug targeting

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:320

Article

Cregg, P. J.¹  Murphy, Kieran¹  Mardinoglu, Adil¹ 

[1] Waterford Inst Technol, SEAM Res Ctr, Mat Characterisat & Proc Grp, Waterford, Ireland

关键词: Magnetic drug targeting;    High gradient magnetic separation (HGMS);    Magnetic nanoparticle;    Simulation;    Magnetic seed;   

DOI  :  10.1016/j.jmmm.2008.06.021

来源: Elsevier

【 摘 要 】

The implant assisted magnetic targeted drug delivery system of Aviles, Ebner and Ritter, which uses high gradient magnetic separation (HGMS) is considered. In this 2D model large ferromagnetic particles are implanted as seeds to aid collection of multiple domain nanoparticles (radius approximate to 200 nm). Here, in contrast, single domain magnetic nanoparticles (radius in 20-100 nm) are considered and the Langevin function is used to describe the magnetization. Simulations based on this model were performed using the open source C + + finite volume library OpenFOAM. The simulations indicate that use of the Langevin function predicts greater collection efficiency than might be otherwise expected. (C) 2008 Elsevier B.V. All rights reserved.

【 授权许可】

Free