Magnetic hyaluronate hydrogels: preparation and characterization

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:380

Article; Proceedings Paper

Toth, Ildiko Y.¹  Veress, Gabor¹  Szekeres, Marta¹  Illes, Erzsebet¹  Tombacz, Etelka¹ 

[1] Univ Szeged, Dept Phys Chem & Mat Sci, H-6720 Szeged, Hungary

关键词: Magnetite;    Chondroitin-sulfate-A;    Hyaluronate;    Magnetic hydrogels;    Surface modification;    Intra-articular injection;   

DOI  :  10.1016/j.jmmm.2014.10.139

来源: Elsevier

【 摘 要 】

A novel soft way of hyaluronate (HyA) based magnetic hydrogel preparation was revealed. Magnetite nanoparticles (MNPs) were prepared by co-precipitation. Since the naked MNPs cannot be dispersed homogenously in HyA-gel, their surface was modified with natural and biocompatible chondroitin-sulfate-A (CSA) to obtain CSA-coated MNPs (CSA@MNPs). The aggregation state of MNPs and that loaded with increasing amount of CSA up to 1 mmol/g was measured by dynamic light scattering at pH similar to 6. Only CSA@MNP with >= 0.2 mmol/g CSA content was suitable for magnetic HyA-gel preparation. Rheological studies showed that the presence of CSA@MNP with up to 2 g/L did not affect the hydrogel's rheological behavior significantly. The results suggest that the HyA-based magnetic hydrogels may be promising formulations for future biomedical applications, e.g. as intra-articular injections in the treatment of osteoarthritis. (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

Free