Assessment of differential magnetic susceptibility in nanoparticles: Effects of changes in viscosity and immobilisation

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:514

Article

Riahi, Kalthoum¹  van de Loosdrecht, Melissa M.¹  Alic, Lejla¹  ten Haken, Bennie¹ 

[1] Univ Twente, Tech Med Ctr, Magnet Detect & Imaging Grp, Enschede, Netherlands

关键词: Superparamagnetic iron-oxide nanoparticles;    Brownian relaxation;    Neel relaxation;    Differential magnetic susceptibility;   

DOI  :  10.1016/j.jmmm.2020.167238

来源: Elsevier

【 摘 要 】

The nonlinear magnetic behaviour of superparamagnetic iron-oxide nanoparticles (SPIONs) has attracted interest as a valuable feature for upcoming medical applications. Injecting SPIONs into the human body affects their magnetic properties through the formation of protein corona or cell immobilisation. It is therefore important to study the effects of environmental changes on the magnetic susceptibility of SPIONs. A superparamagnetic quantifier (SPaQ) is used here to assess the differential magnetic susceptibility of three commercially available SPIONs: Synomag (R), Resovist (R) and Sienna + (R). The following experiments were carried out to mimic the influence of the biological environment on the magnetic responses of SPIONs: (i) varying the viscosity of the medium; and (ii) immobilising the nanoparticles by freeze-drying. Differential magnetisation curves as a function of the applied magnetic field were visualised to reveal the dynamic magnetic behaviour of SPIONs in both experiments. Synomag (R) displayed the lowest decrease (similar to 5%) in differential magnetic susceptibility compared to Resovist (R) (similar to 33%) and Sienna + (R) (similar to 21%), for a change from water to a high-viscosity fluid. Although Synomag (R) showed a clear drop in differential magnetic susceptibility (similar to 58%) after freeze-drying, it still appears to be a promising candidate for clinical applications due to its low sensitivity to changes in viscosity.

【 授权许可】

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