Heart rate variability and salivary cortisol in very preterm children during school age

PSYCHONEUROENDOCRINOLOGY

卷:87

Article

Urfer-Maurer, Natalie¹  Ludyga, Sebastian²  Stalder, Tobias³  Brand, Serge^2,4,5  Holsboer-Trachsler, Edith⁴  Gerber, Markus²  Grob, Alexander¹  Weber, Peter⁶  Lemola, Sakari⁷ 

[1] Univ Basel, Dept Psychol, Basel, Switzerland

[2] Univ Basel, Dept Sport Exercise & Hlth, Sport Sci Sect, Basel, Switzerland

[3] Univ Siegen, Clin Psychol, Siegen, Germany

[4] Univ Basel, Psychiat Clin, Ctr Affect Stress & Sleep Disorders, Basel, Switzerland

[5] KUMS, Sleep Disorders Res Ctr, Kermanshah, Iran

[6] Univ Childrens Hosp Basel, Div Neuropediat & Dev Med, Basel, Switzerland

[7] Univ Warwick, Dept Psychol, Univ Rd, Coventry CV4 7AL, W Midlands, England

关键词: Preterm birth;    Heart rate variability;    HPA axis activity;    Salivary cortisol;    School-aged children;    Polysomnography;   

DOI  :  10.1016/j.psyneuen.2017.10.004

来源: Elsevier

【 摘 要 】

The autonomic nervous system (ANS) plays a major role in the human stress response and reflects physical and psychological adaptability to a changing environment. Long-term exposure to early life stressors may alter the function of the ANS. The present study examines differences in the ANS between children born very preterm and full-term as well as the association between the ANS and the hypothalamic-pituitary-adrenal (HPA) axis, the other main branch of the human stress system. Fifty-four healthy children born very preterm ( < 32nd gestational week) and 67 full-term children aged 7-12 years provided data for the present study. Polysomnography (PSG) assessments were obtained during a night at the children's home in lying position at rest (wake) and during different sleep stages (stage 2 sleep, slow wave sleep, rapid-eye-movement sleep). Autonomic function was assessed by use of heart rate variability, specifically low frequency power (LF), high frequency power (HF), total spectral power (Tot Pow), and the LF/HF ratio. HPA axis activity was measured using salivary cortisol the next morning at awakening, 10, 20, and 30 min later. Children born very preterm had lower LF/HF ratio during wake and stage 2 sleep compared to full-term children. Moreover, higher LF, Tot Pow, and LF/HF ratio during wake, stage 2 sleep, and REM sleep were related to more post-awakening cortisol secretion. The present study provides evidence on long-term ANS alterations after very preterm birth. Moreover, findings suggest a relation between the ANS and the HPA axis and therefore support the notion of mutual feedback between the two human stress systems.

【 授权许可】

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