Lower subjective social status exaggerates interleukin-6 responses to a laboratory stressor

PSYCHONEUROENDOCRINOLOGY

卷:38

Article

Derry, Heather M.^1,2  Fagundes, Christopher P.³  Andridge, Rebecca⁴  Glaser, Ronald^1,5,6,7  Malarkey, William B.^1,5,7  Kiecolt-Glaser, Janice K.^1,2,7,8 

[1] Ohio State Univ, Coll Med, Inst Behav Med Res, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Hlth Dispar Res, Houston, TX 77030 USA

[4] Ohio State Univ, Coll Publ Hlth, Div Biostat, Columbus, OH 43210 USA

[5] Ohio State Univ, Coll Med, Dept Internal Med, Columbus, OH 43210 USA

[6] Ohio State Univ, Coll Med, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[7] Ohio State Univ, Coll Med, Ctr Comprehens Canc, Columbus, OH 43210 USA

[8] Ohio State Univ, Coll Med, Dept Psychiat, Columbus, OH 43210 USA

关键词: Subjective social status;    Inflammation;    Interleukin-6 (IL-6);    Laboratory stressor;   

DOI  :  10.1016/j.psyneuen.2013.06.026

来源: Elsevier

【 摘 要 】

Growing evidence suggests that lower subjective social status (SSS), which reflects where a person positions himself on a social ladder in relation to others, is independently related to poor health. People who rate themselves lower in status also experience more frequent stressors and report higher stress than those who rate themselves higher in status, and chronic stress can enhance an individual's response to subsequent stressors. To address whether SSS predicted stress-induced interleukin-6 (IL-6) changes, we assessed 138 healthy adults at rest and following the Trier Social Stress Test (TSST). Participants completed the TSST at two study visits, separated by 4 months. People who placed themselves lower on the social ladder had larger IL-6 responses from baseline to 45 min post-stressor (p = 0.01) and from baseline to 2 h post-stressor (p = 0.03) than those who placed themselves higher on the social ladder. Based on a ratio of subjective threat and coping ratings of the stress task, participants who viewed themselves as lower in status also tended to rate the speech task as more threatening and less manageable than those who viewed themselves as higher in status (p = 0.05). These data suggest that people with tower perceived status experience greater physiological and psychological burden from brief stressors compared to those with higher perceived status. Accordingly, responses to stressors may be a possible mechanistic link among SSS, stress, and health. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free