Chronic stress increases vulnerability to diet-related abdominal fat, oxidative stress, and metabolic risk

PSYCHONEUROENDOCRINOLOGY

卷:46

Article

Aschbacher, Kirstin^1,2  Kornfeld, Sarah³  Picard, Martin^4,5  Puterman, Eli¹  Havel, Peter J.⁶  Stanhope, Kimber⁶  Lustig, Robert H.^7,8  Epel, Elissa¹ 

[1] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

[2] Inst Integrat Hlth, Baltimore, MD USA

[3] Alliant Int Univ, Calif Sch Profess Psychol, San Francisco, CA USA

[4] Childrens Hosp Philadelphia, Ctr Mitochondrial & Epigen Med, Philadelphia, PA 19104 USA

[5] Univ Penn, Philadelphia, PA 19104 USA

[6] Univ Calif Davis, Dept Mol Biosci & Nutr, Davis, CA 95616 USA

[7] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA

[8] Univ Calif San Francisco, Inst Hlth Policy Studies, San Francisco, CA USA

关键词: Psychological stress;    Obesity;    Abdominal adiposity;    Metabolic syndrome;    Pre-diabetes;   

DOI  :  10.1016/j.psyneuen.2014.04.003

来源: Elsevier

【 摘 要 】

Background: In preclinical studies, the combination of chronic stress and a high sugar/fat diet is a more potent driver of visceral adiposity than diet alone, a process mediated by peripheral neuropeptide Y (NPY). Methods: In a human model of chronic stress, we investigated whether the synergistic combination of highly palatable foods (HPF; high sugar/fat) and stress was associated with elevated metabolic risk. Using a case-control design, we compared 33 post-menopausal caregivers (the chronic stress group) to 28 age-matched low-stress control women on reported HPF consumption (modified Block Food Frequency Questionnaire), waistline circumference, truncal fat ultrasound, and insulin sensitivity using a 3-h oral glucose tolerance test. A fasting blood draw was assayed for plasma NPY and oxidative stress markers (8-hydroxyguanosine and F2-Isoprostanes). Results: Among chronically stressed women only, greater HPF consumption was associated with greater abdominal adiposity, oxidative stress, and insulin resistance at baseline (all p's <= .01). Furthermore, plasma NPY was significantly elevated in chronically stressed women (p < .01), and the association of HPF with abdominal adiposity was stronger among women with high versus low NPY. There were no significant predictions of change over 1-year, likely due to high stability (little change) in the primary outcomes over this period. Discussion: Chronic stress is associated with enhanced vulnerability to diet-related metabolic risk (abdominal adiposity, insulin resistance, and oxidative stress). Stress-induced peripheral NPY may play a mechanistic role. (C) 2014 Published by Elsevier Ltd.

【 授权许可】

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