Accelerated DNA methylation age: Associations with PTSD and neural integrity

PSYCHONEUROENDOCRINOLOGY

卷:63

Article

Wolf, Erika J.^1,2  Logue, Mark W.^3,4,5  Hayes, Jasmeet P.^1,2,7  Sadeh, Naomi^1,2  Schichman, Steven A.⁶  Stone, Annjanette⁶  Salat, David H.⁷  Milberg, William^8,9,10  McGlinchey, Regina^8,9,10  Miller, Mark W.^1,2 

[1] VA Boston Healthcare Syst, Natl Ctr PTSD, Behav Sci Div, Boston, MA USA

[2] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA

[3] VA Boston Healthcare Syst, Res Serv, Boston, MA USA

[4] Boston Univ, Sch Med, Biomed Genet, Boston, MA 02118 USA

[5] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

[6] Cent Arkansas Vet Healthcare Syst, Res Serv, Pharmacogen Anal Lab, Little Rock, AR USA

[7] VA Boston Healthcare Syst, Neuroimaging Res Vet Ctr, Boston, MA USA

[8] VA Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr, Boston, MA USA

[9] VA Boston Healthcare Syst, Ctr TBI & Stress Disorders, Translat Res, Boston, MA USA

[10] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA

关键词: Accelerated aging;    DNA methylation;    PTSD;    Diffusion tensor imaging;    Genu;    Working memory;   

DOI  :  10.1016/j.psyneuen.2015.09.020

来源: Elsevier

【 摘 要 】

Background: Accumulating evidence suggests that posttraumatic stress disorder (PTSD) may accelerate cellular aging and lead to premature morbidity and neurocognitive decline. Methods: This study evaluated associations between PTSD and DNA methylation (DNAm) age using recently developed algorithms of cellular age by Horvath (2013) and Hannum et al. (2013). These estimates reflect accelerated aging when they exceed chronological age. We also examined if accelerated cellular age manifested in degraded neural integrity, indexed via diffusion tensor imaging. Results: Among 281 male and female veterans of the conflicts in Iraq and Afghanistan, DNAm age was strongly related to chronological age (rs similar to .88). Lifetime PTSD severity was associated with Hannum DNAm age estimates residualized for chronological age (beta = .13, p = .032). Advanced DNAm age was associated with reduced integrity in the genu of the corpus callosum (beta = .17, p = .009) and indirectly linked to poorer working memory performance via this region (indirect beta = -.05, p = .029). Horvath DNAm age estimates were not associated with PTSD or neural integrity. Conclusions: Results provide novel support for PTSD-related accelerated aging in DNAm and extend the evidence base of known DNAm age correlates to the domains of neural integrity and cognition. Published by Elsevier Ltd.

【 授权许可】

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