Socioeconomic and race/ethnic differences in daily salivary cortisol profiles: The Multi-Ethnic Study of Atherosclerosis

PSYCHONEUROENDOCRINOLOGY

卷:35

Article

Hajat, Anjum¹  Seeman, Teresa²  Shrager, Sandi³  Ranjit, Nalini⁴  Castro, Cecilia⁵  Watson, Karol⁶  Sanchez, Brisa⁷  Kirschbaum, Clemens⁸ 

[1] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ctr Social Epidemiol & Populat Hlth, Ann Arbor, MI 48109 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Geriatr, Los Angeles, CA 90095 USA

[3] Univ Washington, Dept Biostat, Collaborat Hlth Studies Coordinating Ctr, Seattle, WA 98115 USA

[4] Univ Texas Hlth Sci Ctr, Sch Publ Hlth, Houston, TX 77030 USA

[5] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Cardiol, Los Angeles, CA 90095 USA

[7] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA

[8] Tech Univ Dresden, Dept Psychol, D-01062 Dresden, Germany

关键词: Salivary cortisol;    Cortisol diurnal pattern;    Race/ethnicity;    Socioeconomic status;    Cortisol awakening response;    Stress;   

DOI  :  10.1016/j.psyneuen.2009.12.009

来源: Elsevier

【 摘 要 】

It has often been hypothesized that stress and its biological consequences mediate the relationship between low socioeconomic status (SES) or minority status and poor cardiovascular disease outcomes. The objective of this study was to determine if daily cortisol patterns, a biomarker of the stress response, differ by race/ethnicity and socioeconomic status. Data were collected from 935 Black, White and Hispanic adults age 48-90 years old. Salivary cortisol samples were collected six times per day over 3 days: at awakening, 30 min later, at 1000 h, noon, 1800 h and at bedtime. Blacks and Hispanics had lower levels of wake-up cortisol and less steep early declines, while Blacks had flatter and Hispanics steeper late day declines relative to Whites. Similarly the low socioeconomic status group also had lower levels of wake-up cortisol and less steep decline during the early part of the day. These patterns remained after adjustment for health behaviors and psychosocial factors. This study finds an association between salivary cortisol and race/ethnicity and SES in a multi-ethnic study population. Further work is needed to determine the health consequences of these differences. (C) 2009 Elsevier Ltd. All rights reserved.

【 授权许可】

Free