Salivary cortisol protocol adherence and reliability by socio-demographic features: The Multi-Ethnic Study of Atherosclerosis

PSYCHONEUROENDOCRINOLOGY

卷:43

Article

Golden, Sherita Hill^1,2  Sanchez, Brisa N.³  DeSantis, Amy S.⁴  Wu, Meihua³  Castro, Cecilia^5,6  Seeman, Teresa E.^7,8  Tadros, Sameh^7,8  Shrager, Sandi⁹  Roux, Ana V. Diez⁴ 

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21287 USA

[3] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Epidemiol, Ctr Social Epidemiol & Populat Hlth, Ann Arbor, MI 48109 USA

[5] Columbia Univ, Dept Epidemiol, New York, NY 10032 USA

[6] Columbia Univ, Dept Med, New York, NY 10032 USA

[7] Univ Calif Los Angeles, Dept Epidemiol, Los Angeles, CA 10945 USA

[8] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 10945 USA

[9] Univ Washington, Dept Biostat, Seattle, WA 98115 USA

关键词: Salivary cortisol;    Cortisol awakening response (CAR);    Diurnal cortisol;    Reliability;    Compliance;    Population-based study;   

DOI  :  10.1016/j.psyneuen.2014.01.025

来源: Elsevier

【 摘 要 】

Collection of salivary cortisol has become increasingly popular in large population-based studies. However, the impact of protocol compliance on day-to-day reliabilities of measures, and the extent to which reliabilities differ systematically according to socio-demo-graphic characteristics, has not been well characterized in large-scale population-based studies to date. Using data on 935 men and women from the Multi-Ethnic Study of Atherosclerosis, we investigated whether sampling protocol compliance differs systematically according to socio-demographic factors and whether compliance was associated with cortisol estimates, as well as whether associations of cortisol with both compliance and socio-demographic characteristics were robust to adjustments for one another. We further assessed the day-to-day reliability for cortisol features and the extent to which reliabilities vary according to socio-demographic factors and sampling protocol compliance. Overall, we found higher compliance among persons with higher levels of income and education. Lower compliance was significantly associated with a less pronounced cortisol awakening response (CAR) but was not associated with any other cortisol features, and adjustment for compliance did not affect associations of socio-demographic characteristics with cortisol. Reliability was higher for area under the curve (AUC) and wake up values than for other features, but generally did not vary according to socio-demographic characteristics, with few exceptions. Our findings regarding intra-class correlation coefficients (ICCs) support prior research indicating that multiple day collection is preferable to single day collection, particularly for CAR and slopes, more so than wakeup and AUC. There were few differences in reliability by socio-demographic characteristics. Thus, it is unlikely that group-specific sampling protocols are warranted. (C) 2014 Elsevier Ltd. All rights reserved.

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