Heart rate variability measure in breast cancer patients and survivors: A systematic review

PSYCHONEUROENDOCRINOLOGY

卷:68

Review

Arab, Claudia¹  Martins Dias, Daniel Penteado²  de Almeida Barbosa, Renata Thais³  de Carvalho, Tatiana Dias³  Valenti, Vitor Engracia⁴  Crocetta, Tania Brusque³  Ferreira, Marcelo³  de Abreu, Luiz Carlos^3,5  Ferreira, Celso¹ 

[1] Univ Fed Sao Paulo UNIFESP, Escola Paulista Med, Dept Med Cardiol, 715 Napoleao Barros St, BR-04024002 Sao Paulo, SP, Brazil

[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Fisiol, 3900 Bandeirantes Av, BR-14049900 Ribeirao Preto, SP, Brazil

[3] Fac Med ABC FMABC, Dept Saude Coletividade, 821 P Rincipe De Gales Av, BR-09060650 Santo Andre, SP, Brazil

[4] Univ Estadual Paulista Julio de Mesquite Filho UN, Fac Filosofia & Ciencias, Dept Fonoaudiol, Ctr Estudos Sistema Nervoso Autonomo, 737 Hygino Muzzi Filho Av, BR-17525901 Marilia, SP, Brazil

[5] Univ Sao Paulo, Fac Saude Publ, 715 Doutor Arnaldo Av, BR-01246904 Sao Paulo, SP, Brazil

关键词: Breast neoplasm;    Autonomic nervous system;    Cardiovascular physiology;    Sympathetic nervous system;    Parasympathetic nervous system;    Cardiac electrophysiology;   

DOI  :  10.1016/j.psyneuen.2016.02.018

来源: Elsevier

【 摘 要 】

Purpose: In the current study, we aimed to review literature findings showing the clinical importance of cardiac autonomic modulation assessed by heart rate variability analysis in breast cancer (BC) patients and survivors. Methods: We conducted a systematic review according to The PRISMA Statement in Medline, Scopus and Web of Science (-2015) databases. The search was limited to articles in English language, published in peer-reviewed journals, and with adult age samples only (e.g., women, patients, or survivors, diagnosed with BC in any stage). We included observational studies and randomized trials. Detailed heart rate variability analysis (instruments, data collection protocol, and analysis methods) was required. Search terms included autonomic nervous system, heart rate variability, sympathetic and parasympathetic nervous system, autonomic dysfunction, vagal nervous and breast neoplasms, breast cancer and breast tumor. Results: Twelve studies were included in this review. The clinical importance of cardiac autonomic modulation assessed by heart rate variability analysis in BC patients and survivors is demonstrated by association with effects of BC surgery, and treatments, and the adverse effects of surgery and treatments on survivors (e.g., cardiotoxicity, fatigue, and stress). Limitations: The strength of evidence of included studies is low: small samples size and heterogeneity, presence of confounders, and observational studies design. Conclusions: The heart rate variability analysis could be used as a complementary non-invasive tool for the early diagnosis and better prognosis of autonomic dysfunction, and survival in BC patients. There are many potential clinical applications of heart rate variability analysis in BC patients, and the employment of such approaches could lead to lower impairment of autonomic function in this individuals. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free