Progesterone improves cognitive performance and attenuates smoking urges in abstinent smokers

PSYCHONEUROENDOCRINOLOGY

卷:36

Article

Sofuoglu, Mehmet¹  Mouratidis, Maria²  Mooney, Marc³ 

[1] Yale Univ, Dept Psychiat, VA Connecticut Healthcare Syst, Sch Med, West Haven, CT 06516 USA

[2] Coll Notre Dame Maryland, Dept Psychol & Social, Baltimore, MD USA

[3] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA

关键词: Progesterone;    Cognitive performance;    Nicotine dependence;    Sex differences;    Menstrual cycle phase;    Sex differences;   

DOI  :  10.1016/j.psyneuen.2010.07.005

来源: Elsevier

【 摘 要 】

Background: Progesterone, a steroid hormone, has been implicated in many CNS functions including reward, cognition, and neuroprotection. The goal of this study was to examine the dose-dependent effects of progesterone on cognitive performance, smoking urges, and smoking behavior in smokers. Methods: Thirty female and thirty-four male smokers participated in a double-blind, placebo-controlled study. Female smokers were in the early follicular phase of their menstrual cycle during study participation. Smokers were randomly assigned to either 200 or 400 mg/day of progesterone or placebo, given in two separate doses, during clinic visit. The first 3 days of the treatment period, smokers abstained from smoking, which was verified with breath CO levels. Smokers attended an experimental session on day 4 where the number of cigarettes smoked were recorded starting 2 h after the medication treatment. Results: Progesterone treatment, 200 mg/day, significantly improved cognitive performance in the Stroop and the Digit Symbol Substitution Test. Progesterone at 400 mg/day was associated with reduced urges for smoking but did not change ad lib smoking behavior. Conclusions: These findings suggest a potential therapeutic value of progesterone for smoking cessation. (C) 2010 Elsevier Ltd. All rights reserved.

【 授权许可】

Free