The intergenerational interplay of adversity on salivary inflammation in young children and caregivers

PSYCHONEUROENDOCRINOLOGY

卷:128

Article

Huffhines, Lindsay^1,2  Jackson, Yo^3,4  McGuire, Austen⁴  Schreier, Hannah M. C.⁵ 

[1] Brown Univ, Dept Psychiat & Human Behav, Alpert Med Sch, 222 Richmond St, Providence, RI 02903 USA

[2] EP Bradley Hosp, Bradley Hasbro Childrens Res Ctr, 1 Hoppin St, Providence, RI 02903 USA

[3] Penn State Univ, Dept Psychol, 219 Moore, University Pk, PA 16802 USA

[4] Univ Kansas, Clin Child Psychol Program, 1000 Sunnyside Ave, Lawrence, KS 66045 USA

[5] Penn State Univ, Dept Biobehav Hlth, 219 Biobehav Hlth Bldg, University Pk, PA 16802 USA

关键词: Adverse childhood experiences;    Maltreatment;    Trauma;    Intergenerational transmission;    Early childhood;    Inflammation;   

DOI  :  10.1016/j.psyneuen.2021.105222

来源: Elsevier

【 摘 要 】

Systemic inflammation links exposure to early childhood adversity to later disease. The associations among adversity and disease risk might in part operate through poor oral hygiene and subsequent periodontal inflammation, which can be measured in saliva. Few studies, however, have examined the association between adversity and salivary inflammation in young children. Further, there is a dearth of literature investigating adverse experiences and salivary inflammation in children and caregivers together, limiting our understanding of the intergenerational, dual effects of adversity on inflammation for both members of the caregiver-child dyad. This study tested child and caregiver adversity and their associations with an inflammatory composite (i.e., IL-6, IL-113, IL-8, TNF-alpha) and CRP in 93 preschool-age children and their caregivers. Caregivers reported on their child's experiences of adversity, as well as on their own adverse experiences, using a comprehensive questionnaire synthesized from previous checklists for complete coverage of possible adverse events. Results showed that caregivers' salivary inflammatory markers (i.e., IL-6, IL-113, IL-8, TNF-alpha, and CRP) were not significantly correlated with the same five inflammatory markers in children's saliva. Among children, adversity was associated with significantly higher levels of the inflammatory composite, though not CRP. This association was amplified among children whose caregivers also experienced more adversity during adulthood. Among caregivers, childhood adversity and adulthood adversity were each independently associated with significantly higher levels of the inflammatory composite and CRP. The association between caregivers' own childhood adversity and inflammation was amplified among caregivers whose children also experienced more adversity during their childhoods. These findings provide preliminary evidence for the possible dual role of young children's and caregivers' adverse experiences in contributing to salivary inflammation for both members of the dyad, suggesting possible implications for systemic inflammation and future disease.

【 授权许可】

Free