Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: Interactions with reproductive status in female rats

PSYCHONEUROENDOCRINOLOGY

卷:33

Article

Levant, Beth^1,4  Ozias, Marlies K.¹  Davis, Paul F.¹  Winter, Michelle¹  Russell, Kristin L.¹  Carlson, Susan E.^2,3,4  Reed, Gregory A.¹  McCarson, Kenneth. E.^1,4 

[1] Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, Kansas City, KS 66160 USA

[2] Univ Kansas, Med Ctr, Dept Nutr & Dietet, Kansas City, KS 66160 USA

[3] Univ Kansas, Med Ctr, Dept Pediat, Kansas City, KS 66160 USA

[4] Univ Kansas, Med Ctr, Kansas Intellectual & Dev Disabil Res Ctr, Kansas City, KS 66160 USA

关键词: Omega-3;    polyunsaturated fatty acid;    Brain-derived neurotrophic factor;    Serotonin 1A receptor;    Forced swim;    Postpartum;    Corticosterone;   

DOI  :  10.1016/j.psyneuen.2008.06.012

来源: Elsevier

【 摘 要 】

Decreased tissue levels of docosahexaenoic acid (DHA; 22:6n-3) are implicated in the etiologies of non-puerperal and postpartum depression. With the aim of determining neurobiological sequelae of decreased brain DHA content, this study examined the effects of a loss of brain DHA content and concurrent reproductive status in adult female Long-Evans rats. An alpha-linolenic acid-deficient diet and breeding protocols were used to produce virgin and parous female rats with cortical phospholipid DHA Levels 23-26% lower than virgin and parous rats fed a control diet containing adequate alpha-linolenic acid. Parous dams were tested/euthanized at weaning (postnatal. day 20) of the second litter; virgin females, during diestrus. Decreased brain DHA was associated with decreased hippocampal BDNF gene expression and increased relative corticosterone response to an intense stressor, regardless of reproductive status. In virgin females with decreased brain DHA, serotonin content and turnover in frontal cortex were decreased compared to virgin females with normal brain DHA. In parous dams with decreased brain DHA, the density of 5-HT1A receptors in the hippocampus was increased, corticosterone response to an intense stressor was increased, and the Latency to immobility in the forced swim test was decreased compared to parous dams with normal DHA. These findings demonstrate neurobiological alterations attributable to decreased brain DHA or an interaction of parous status and brain DHA level. Furthermore, the data are consistent with findings in depressed humans, and thus support a role for DHA as a factor in the etiologies of depressive illnesses, particularly postpartum depression. (C) 2008 Elsevier Ltd. All rights reserved.

【 授权许可】

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