Estrogen receptor gene variants are associated with anxiety disorders in older women

PSYCHONEUROENDOCRINOLOGY

卷:36

Article

Ryan, Joanne^1,2,3  Scali, Jacqueline^1,2  Carriere, Isabelle^1,2  Scarabin, Pierre-Yves⁴  Ritchie, Karen^1,2,5  Ancelin, Marie-Laure^1,2 

[1] Hop La Colombiere, INSERM, U1061, F-34093 Montpellier 5, France

[2] Univ Montpellier 1, F-34000 Montpellier, France

[3] Hop Albert Chenevier, Fdn FondaMental, Creteil, France

[4] Univ Paris 11, INSERM, U1018, F-94807 Villejuif, France

[5] Univ London Imperial Coll Sci Technol & Med, Fac Med, London, England

关键词: Estrogen receptor ESR1 and ESR2;    Single nucleotide polymorphisms;    Anxiety;    Generalised anxiety disorder;    Phobia;    Elderly women;    Hormone treatment;    Association;   

DOI  :  10.1016/j.psyneuen.2011.04.011

来源: Elsevier

【 摘 要 】

Background: Estrogen is thought to play a key role in anxiety, but it remains unknown whether genetic variants in the estrogen receptors (ERs) can influence the risk of anxiety. This study investigated whether ESR1 and ESR2 gene variants were associated with specific anxiety disorders in postmenopausal women and evaluated the potential modifying effect of hormone treatment (HT) on these associations. Methods: One thousand and ninety-two community-dwelling women aged 65 years and older were recruited as part of the ESPRIT Study in Montpellier, France. Anxiety was assessed using the Mini-International Neuropsychiatry Interview (MINI), according to DSM-IV criteria. Two ESR1 and three ESR2 polymorphisms were genotyped. Results: The most common anxiety disorders were phobia (14.2%) and generalised anxiety disorder (GAD, 8%). The A allele of ESFt2 rs1256049 was associated with an increased risk of GAD [OR: 2.06, 95% CI: 1.09-3.87], while both ESR1 polymorphisms were specifically associated with phobia. The C allele of ESR1 rs2234693 decreased the risk of phobia by 42% [95% CI: 0.41-0.83], and this remained significant even after Bonferroni correction. The G allele of ESR1 rs9340799 was associated with a 31% decreased phobia risk [95% CI: 0.49-0.96]. There was also evidence of a significant gene-environment interaction, where only women who were currently using HT had a reduced risk of phobia with these ESR1 gene variants. Conclusions: This study confirms earlier findings of an association between ESR1 and global anxiety in older women, however these associations varied depending on the anxiety syndrome and the use of HT. The results also suggest that the ESR2 may contribute to the genetic vulnerability to GAD, but these findings require further confirmation. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

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