A novel BDNF polymorphism affects plasma protein levels in interaction with early adversity in rhesus macaques

PSYCHONEUROENDOCRINOLOGY

卷:36

Article

Cirulli, Francesca¹  Reif, Andreas²  Herterich, Sabine³  Lesch, K. Peter²  Berry, Alessandra¹  Francia, Nadia¹  Aloe, Luigi⁴  Barr, Christina S.⁵  Suomi, Stephen J.⁶  Alleva, Enrico¹ 

[1] Ist Super Sanita, Dept Cell Biol & Neurosci, Sect Behav Neurosci, I-00161 Rome, Italy

[2] Univ Wurzburg, UMP, Dept Psychiat & Psychotherapy, Wurzburg, Germany

[3] Univ Wurzburg, Cent Lab, Dept Clin Biochem & Pathobiochem, Wurzburg, Germany

[4] CNR EBRI, Inst Neurobiol & Mol Med, I-00143 Rome, Italy

[5] NIAAA, Sect Comparat Behav Genom, Rockville, MD 20852 USA

[6] NICHD, Comparat Ethol Lab, Poolesville, MD 20837 USA

关键词: Brain-derived neurotrophic factor (BDNF);    Polymorphism;    Stress;    Depression;    Non-human primates;   

DOI  :  10.1016/j.psyneuen.2010.10.019

来源: Elsevier

【 摘 要 】

Early stressful events can increase vulnerability for psychopathology, although knowledge on the effectors is still limited. In this report we describe the characterization of a single nucleotide polymorphism (SNP) in rhesus macaques, which results in a Val to Met transition in the pro-BDNF domain, similar to a well described variant in the human gene. Further, we tested the hypothesis that peripheral levels of BDNF, which is involved in the response to stress and in the pathophysiology of anxiety and depression, might be differentially affected in a non-human primate model of early adverse rearing in a genotype-dependent manner. Males and females rhesus macaques reared either with their mothers (MR), in peer-only groups (PR), or in a surrogate/peer-reared (SPR) condition with limited peer interactions, were used as experimental subjects. BDNF levels were determined at baseline on postnatal days (PND) 14, 30 and 60 by means of specific ELISA procedure. Data indicate that BDNF levels were increased as a result of peer-rearing and that this increase was moderated by the presence of the SNP. Overall these data indicate that a SNP, which results in a Val to Met transition in the pro-BDNF domain, is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene. (C) 2010 Elsevier Ltd. All rights reserved.

【 授权许可】

Free