Anti-inflammatory agents attenuate the passive responses of guinea pig pups: Evidence for stress-induced sickness behavior during maternal separation

PSYCHONEUROENDOCRINOLOGY

卷:32

Article

Hennessy, Michael B. ; Schiml-Webb, Patricia A. ; Miller, Emily E. ; Maken, Deborah S. ; Bullinger, Katie L. ; Deak, Terrence

关键词: sickness behaviors;    acute phase response;    inflammation;    maternal separation;    isolation;    guinea pig;   

DOI  :  10.1016/j.psyneuen.2007.03.004

来源: Elsevier

【 摘 要 】

A previous study found that intracerebroventricular (ICV) infusion of 25 mu g of alpha-MSH reduced the passive responses (crouched stance, eye-closing, piloerection) of guinea pig pups during a 3-h isolation in a novel environment. Because alpha-MSH has broad anti-inflammatory properties, the results suggested that proinflammatory factors play a rote in mediating the behavior of isolated infants. The present study further investigated this possibility. In Experiment 1, injection of tipopolysacchride (LPS) increased the number of 60-s intervals in which pups expressed the same three responses during a 1-h test, and ICV infusion of alpha-MSH significantly reduced the effect of LIDS on crouching and piloerection. In Experiment 2, the prostaglandin synthesis inhibitor indomethacin (10 mg/kg) reduced the number of 60-s intervals in which pups exhibited both crouching and the full suite of passive responses during a 3-h isolation in a novel environment. Together these results provide further support for the hypothesis that the passive behaviors exhibited during prolonged isolation are stress-induced sickness behaviors mediated by proinflammatory factors. (C) 2007 Elsevier Ltd. All rights reserved.

【 授权许可】

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