Effects of chronic intranasal oxytocin on behavior and cerebral glucose uptake in juvenile titi monkeys

PSYCHONEUROENDOCRINOLOGY

卷:113

Article

Del Razo, Rocio Arias¹  Berger, Trish²  Conley, Alan J.³  Freeman, Sara M.¹  Goetze, Leana R.¹  Jacob, Suma⁴  Lawrence, Rebecca H.¹  Mendoza, Sally P.¹  Rothwell, Emily S.¹  Savidge, Logan E.¹  Solomon, Marjorie⁵  Weinstein, Tamara A. R.¹  Witczak, Lynea R.¹  Bales, Karen L.¹ 

[1] Univ Calif Davis, Calif Natl Primate Res Ctr, Dept Psychol, One Shields Ave, Davis, CA 95616 USA

[2] Univ Calif Davis, Dept Anim Sci, One Shields Ave, Davis, CA 95616 USA

[3] Univ Calif Davis, Sch Vet Med, Dept Populat Hlth & Reprod, One Shields Ave, Davis, CA 95616 USA

[4] Univ Minnesota, Dept Psychiat, Ctr Neurobehav Dev, 2450 Riverside Ave, Minneapolis, MN 55454 USA

[5] Univ Calif Davis, MIND Inst, 2825 50th St, Sacramento, CA 95817 USA

关键词: Intranasal oxytocin;    Chronic;    Social behavior;    Anxiety;    Imaging;    Autism;   

DOI  :  10.1016/j.psyneuen.2019.104494

来源: Elsevier

【 摘 要 】

Intranasal oxytocin (IN OXT) has been proposed as a treatment for autism spectrum disorder (ASD); however, little is known about the effects of long-term exposure. This is the first study in a non-human primate species to examine how developmental exposure to chronic IN OXT affects juvenile's interactions with family members, social preference for parents versus strangers, anxiety-like behavior, and cerebral glucose metabolism. Titi monkeys are socially monogamous and biparental; their family bonds share important characteristics with human family bonds. Fourteen males and 15 females were treated intranasally with saline (n = 14) or 0.8 IU/kg OXT (n = 15), daily from 12 to 18 months of age. Compared to SAL-treated animals, OXT-treated animals of both sexes spent significantly more time grooming other family members (F-1 = 8.97, p = 0.006). Overall, OXT-treated subjects were more social (F-1 = 8.35, p= 0.005) during preference tests. OXT-treated females displayed an enhanced preference for their parents (t = 2.265, p= 0.026). OXT-treated males had a blunted preference for their parents and an increase in the time spent near unfamiliar pairs (F1 = 10.89, p = 0.001). During anxiety tests, OXT-treated males refused to complete the task more often than SAL-treated males and had longer latencies (p < 0.0001). Neuroimaging studies revealed that OXT-treated animals had higher glucose uptake across the social salience network as a whole after one month of treatment (F-1,F-9 = 1.07, p = 0.042). Our results suggest moderate prosocial effects of chronic IN OXT, that did not depend on anxiolytic properties. We also found important sex differences that should be considered in a translational context.

【 授权许可】

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