Within-adolescent coupled changes in cortisol with DHEA and testosterone in response to three stressors during adolescence

PSYCHONEUROENDOCRINOLOGY

卷:41

Article

Marceau, Kristine^1,2,3  Shirtcliff, Elizabeth A.⁴  Hastings, Paul D.⁵  Klimes-Dougan, Bonnie⁶  Zahn-Waxler, Carolyn⁷  Dorn, Lorah D.¹  Susman, Elizabeth J.¹ 

[1] Penn State Univ, University Pk, PA 16802 USA

[2] Rhode Isl Hosp, Dept Psychiat, Div Behav Genet, Providence, RI 02903 USA

[3] Brown Univ, Ctr Alcohol & Addict Studies, Providence, RI 02903 USA

[4] Univ New Orleans, New Orleans, LA 70148 USA

[5] Univ Calif Davis, Davis, CA USA

[6] Univ Minnesota, Minneapolis, MN 55455 USA

[7] Univ Wisconsin, Madison, WI 53706 USA

关键词: Cortisol;    Testosterone;    DHEA;    Social stress;    Venipuncture;    Within-person coupling;    Adolescence;   

DOI  :  10.1016/j.psyneuen.2013.12.002

来源: Elsevier

【 摘 要 】

It is hypothesized that hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes function together to maintain adaptive functioning during stressful situations differently in adolescence than the characteristic inverse relations found in adulthood. We examined within-person correlated changes (coupling) in cortisol, DHEA and testosterone in response to parent-adolescent conflict discussion, social performance, and venipuncture paradigms. Data are derived from two samples of boys and girls from the Northeastern US (213 adolescents aged 11-16, M = 13.7, SD= 1.5 years; 108 adolescents aged 9-14, M = 11.99, SD = 1.55) using different biological sampling vehicles (saliva and blood). Results consistently show that across samples, vehicles, and contexts, cortisol and DHEA and cortisol and testosterone are positively coupled in response to environmental stimuli. Findings underscore the importance of considering the effects of multiple hormones together in order to further our understanding of the biological underpinnings of behavior, especially during adolescence, as adolescence is a developmental transition period that may be qualitatively different from adulthood in terms of hormone functioning. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free