Reduction in salivary α-amylase levels following a mind-body intervention in cancer survivors - An exploratory study

PSYCHONEUROENDOCRINOLOGY

卷:38

Article

Lipschitz, David L.^1,2  Kuhn, Renee^1,2  Kinney, Anita Y.^3,4  Donaldson, Gary W.^1,2  Nakamura, Yoshio^1,2 

[1] Univ Utah, Utah Ctr Exploring Mind Body Interact UCEMBI, Pain Res Ctr, Dept Anesthesiol,Sch Med, Salt Lake City, UT 84108 USA

[2] Univ Utah, Sch Med, Dept Anesthesiol, Pain Res Ctr, Salt Lake City, UT 84108 USA

[3] Univ Utah, Huntsman Canc Inst, Canc Control & Populat Sci Program, Sch Med, Salt Lake City, UT 84108 USA

[4] Univ Utah, Sch Med, Dept Internal Med, Salt Lake City, UT 84108 USA

关键词: Biomarker;    Salivary alpha-amylase;    Salivary cortisol;    Cancer survivor;    Mind-body intervention;    Sleep disturbance;    Stress;    Sympathetic nervous system;   

DOI  :  10.1016/j.psyneuen.2012.12.021

来源: Elsevier

【 摘 要 】

Objective: The main aim of this exploratory study was to assess whether salivary alpha-amylase (sAA) and salivary cortisol levels would be positively modulated by sleep-focused mind-body interventions in female and male cancer survivors. Methods: We conducted a randomized controlled trial in which 57 cancer survivors with self-reported sleep disturbance received either a Sleep Hygiene Education (SHE; n = 18) control, or one of two experimental mind-body interventions, namely, Mind-Body Bridging (MBB; n = 19) or Mindfulness Meditation (MM; n = 20). Interventions were three sessions each conducted once per week for three consecutive weeks. Saliva cortisol and sAA were measured at baseline and 1 week after the last session. Participants also completed a sleep scale at the same time points when saliva was collected for biomarker measurement. Results: Our study revealed that at post-intervention assessment, mean sAA levels upon awakening (Waking sample) declined in MBB compared with that of SHE. Mean Waking cortisol levels did not differ among treatment groups but declined slightly in SHE. Self-reported sleep improved across the three interventions at Post-assessment, with largest improvements in the MBB intervention. Conclusion: In this exploratory study, sleep focused mind-body intervention (MBB) attenuated Waking sAA levels, suggesting positive influences of a mind-body intervention on sympathetic activity in cancer survivors with sleep disturbance. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free