The longitudinal association of changes in diurnal cortisol features with fasting glucose: MESA

PSYCHONEUROENDOCRINOLOGY

卷:119

Article

Dias, Jenny Pena¹  Joseph, Joshua J.²  Kluwe, Bjorn²  Zhao, Songzhu^2,3  Shardell, Michelle^4,8  Seeman, Teresa⁵  Needham, Belinda L.⁶  Wand, Gary S.¹  Kline, David^2,3  Brock, Guy^2,3  Castro-Diehl, Cecilia⁷  Golden, Sherita Hill¹ 

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[2] Ohio State Univ, Dept Internal Med, Wexner Med Ctr, 579 McCampbell Hall,1581 Dodd Dr, Columbus, OH 43210 USA

[3] Ohio State Univ, Coll Med, Ctr Biostat, Dept Biomed Informat, Columbus, OH 43210 USA

[4] Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth, Inst Genome Sci, College Pk, MD 20742 USA

[5] Univ Calif Los Angeles, David Geffen Sch Med, Div Geriatr, Los Angeles, CA 90095 USA

[6] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA

[7] Boston Univ, Sect Prevent Med & Epidemiol, Boston, MA 02215 USA

[8] NIA, NIH, Baltimore, MD 21224 USA

关键词: Cortisol;    Diabetes;    Glucose;    Glycemia;    Hypothalamic-pituitary-adrenal axis;   

DOI  :  10.1016/j.psyneuen.2020.104698

来源: Elsevier

【 摘 要 】

Little is known about the longitudinal association between fasting glucose (FG) and the diurnal cortisol profile among those with normal fasting glucose (NFG), impaired fasting glucose (IFG) and diabetes. To assess the temporality of the relationship between cortisol and glucose, we examined the association of: A) change (Delta) in diurnal cortisol curve features with Delta FG; B) prior annual percent change in FG with diurnal cortisol curve features; and C) baseline cortisol curve features with Delta FG over 6 years among participants with NFG, IFG and diabetes in the Multi-Ethnic Study of Atherosclerosis. The main outcome measures were: A) 6-year Delta FG (n = 512); B) diurnal cortisol curve features (wake-up cortisol levels, cortisol awakening response, total area under the curve, overall decline slope and bedtime cortisol) (n = 1275); and C) 6-year Delta FG (n = 700). After full multivariable adjustment among participants with diabetes, each annual percent change increase in wake-up cortisol, total area under the curve (AUC), and overall decline slope was associated with a significant increase in FG over 6 years in all models (all p < 0.05). A 1% prior annual increase in FG was associated with a 2.8 % lower (-2.8 %; 95 % CI: -5.3 % to -0.4 %) bedtime cortisol among participants with NFG at baseline. A 1 % flatter overall decline slope was associated with a 0.19 % increase in subsequent annual % change in FG over 6 years among participants with diabetes. Among participants with diabetes there was a positive association of change in wake-up cortisol, total AUC and overall decline slope with change in FG. Baseline overall decline slope was positively associated with change in FG among the baseline diabetes group. These results suggest a detrimental role of cortisol contributing to glycemia among individuals with diabetes.

【 授权许可】

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