The role of anxiety in cortisol stress response and cortisol recovery in boys with oppositional defiant disorder/conduct disorder

PSYCHONEUROENDOCRINOLOGY

卷:73

Article

Schoorl, Jantiene^1,2  van Rijn, Sophie^1,2  de Wied, Minet³  van Goozen, Stephanie^1,4  Swaab, Hanna^1,2 

[1] Leiden Univ, Dept Clin Child & Adolescent Studies, POB 9555, NL-2300 RB Leiden, Netherlands

[2] Leiden Inst Brain & Cognit, POB 9600, NL-2300 RC Leiden, Netherlands

[3] Univ Utrecht, Dept Adolescent Dev, POB 80140, NL-3508 TC Utrecht, Netherlands

[4] Cardiff Univ, Sch Psychol, POB 901, Cardiff CF10 3AT, S Glam, Wales

关键词: Stress;    Cortisol stress reactivity;    Cortisol recovery;    Oppositional defiant disorder;    Conduct disorder;    Anxiety;   

DOI  :  10.1016/j.psyneuen.2016.08.007

来源: Elsevier

【 摘 要 】

Children with antisocial and aggressive behaviors have been found to show abnormal neurobiological responses to stress, specifically impaired cortisol stress reactivity. The role of individual characteristics, such as comorbid anxiety, in the stress response is far less studied. Furthermore, this study extended previous studies in that not only baseline and reactivity to a psychosocial stressor were examined, but also recovery from a stressor. These three phases of cortisol could be impacted differentially in boys with oppositional defiant disorder/conduct disorder (ODD/CD) with (+ANX) and without anxiety (-ANX). The results revealed that cortisol patterns in response to psychosocial stress were different for boys with ODD/CD +ANX (n =32), ODD/CD-ANX (n=22) and non-clinical controls (NC) (n = 34), with age range of 7.8-12.9 years. The ODD/CD-ANX group showed lower overall cortisol levels than the NC group. When considering the three phases of cortisol separately, the ODD/CD-ANX group had lower baseline cortisol levels relative to the other groups, whereas the ODD/CD +ANX showed an impaired cortisol recovery response. Within those with ODD/CD, callous-unemotional traits were predictive of high baseline cortisol levels. Also, anxiety predicted high baseline and recovery cortisol levels, whereas a high number of CD symptoms predicted reduced cortisol stress reactivity. These results clearly indicate that comorbid anxiety is an important factor in explaining differences in stress response profiles in boys with ODD/CD; although boys with CD/ODD are generally characterized by an impaired cortisol stress response, we found that those with comorbid anxiety showed impaired cortisol recovery, whereas those without anxiety showed reduced baseline cortisol levels. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free