Emerging literature in the Microbiota-Brain Axis and Perinatal Mood and Anxiety Disorders

PSYCHONEUROENDOCRINOLOGY

卷:95

Article

Rackers, Hannah S.¹  Thomas, Stephanie²  Williamson, Kelsey³  Posey, Rachael^4,5  Kimmel, Mary C.¹ 

[1] Univ N Carolina, Sch Med, Dept Psychiat, 304 MacNider Hall,CB 7160, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, 245 Rosenau Hall,CB 7461, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Sch Med, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Hlth Sci Lib, Chapel Hill, NC 27599 USA

[5] North Carolina State Univ, William Rand Kenan Jr Lib Vet Med, Raleigh, NC 27607 USA

关键词: Depression;    Anxiety;    Microbiome;    Pregnancy;    Stress;    Immunity;   

DOI  :  10.1016/j.psyneuen.2018.05.020

来源: Elsevier

【 摘 要 】

Perinatal Mood and Anxiety Disorders (PMAD) are common and can cause significant morbidity and mortality for mother and child. A healthy perinatal period requires significant adaptations; however, systems can become imbalanced resulting in depressive and anxiety symptoms. The interface between the microbiome, the immune system, and the stress system may be a model for understanding mechanisms underlying PMAD. Emerging literature from general populations regarding immune, hormone, and HPA axis changes in relation to the microbiome combined with literature on immune, gonadotropin, and stress systems in the perinatal period provides a background. We systematically investigated literature in the developing field of the microbiome in relation to PMAD. Our inclusion criteria were 1) reporting measure of maternal mood, stress, or anxious or depressed behavior; 2) in the perinatal period, defined as pregnancy through one year postpartum; and 3) reporting measure of maternal microbiome including manipulations of the microbiome through prebiotics, probiotics, or interventions with microbial byproducts. The review identified research studying associations between stress and maternal microbiome; dietary impacts on microbial composition, mood, and stress; and the relationship between the microbiome and the immune system through immunoregulatory mechanisms. Important themes identified include: the importance of studying the maternal microbiome and measures of stress, anxiety, and depression and that multi-hit models will be needed as research strives to determine the effects of multiple mechanisms working in concert.

【 授权许可】

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