Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression

PSYCHONEUROENDOCRINOLOGY

卷:38

Article

Mocking, Roel J. T.¹  Ruhe, Henricus G.¹  Assies, Johanna¹  Lok, Anja¹  Koeter, Maarten W. J.¹  Visser, Ieke¹  Bockting, Claudi L. H.²  Schene, Aart H.¹ 

[1] Univ Amsterdam, Acad Med Ctr, Dept Psychiat, Program Mood Disorders, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Groningen, Dept Clin Psychol, Groningen, Netherlands

关键词: Psychiatry;    Depressive disorder;    Major;    Glucocorticoids;    Cortisol;    Recurrence;    Fatty acids;    n-3 PUFA;    Eicosapentaenoic acid;    Docosahexaenoic acids;    Metabolic networks and pathways;   

DOI  :  10.1016/j.psyneuen.2013.01.013

来源: Elsevier

【 摘 要 】

Alterations in hypothalamic-pituitary-adrenal (HPA)-axis activity and fatty acid (FA)-metabolism have been observed in (recurrent) major depressive disorder (MDD). Through the pathophysiological roles of FAs in the brain and cardiovascular system, a hypothesized relationship between HPA-axis activity and FA-metabolism could form a possible missing link accounting for the association of HPA-axis hyperactivity with recurrence and cardiovascular disease in MDD. In 137 recurrent MDD-patients and 73 age- and sex-matched controls, we therefore investigated associations between salivary cortisol (morning and evening) and the following indicators of FA-metabolism measured in the red blood cell membrane: (I) three main FAs [eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA)], and (II) structural FA indices (unsaturation, chain length, peroxidation) calculated from concentrations of 29 FAs to delineate overall FA-characteristics. In addition, we compared these associations in patients with those in controls. In patients, evening cortisol concentrations were significantly negatively associated with DHA (B = -1.358; SE = 0.499; t = -2.72; p = .006), the unsaturation index (B = -0.021; SE = 0.009; t = -2.42; p = .018), chain length index (B = -0.060; SE = 0.025; t = -2.41; p = .019), and peroxidation index (B = -0.029; SE = 0.012; t = -2.48; p = .015). The relations between cortisol and the latter three variables were significantly negative in patients relative to controls. Significance remained after correction for confounders. Our results suggest a relationship between HPA-axis activity and FA-metabolism in recurrent MDD. Future randomized experimental intervention studies using clinical outcome measures could help to further elucidate the suggested effects of hypercortisolemia in the brain and cardiovascular system in recurrent MDD. (C) 2013 Elsevier Ltd. All rights reserved.

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