Diurnal salivary cortisol and nativity/duration of residence in Latinos: The Multi-Ethnic Study of Atherosclerosis

PSYCHONEUROENDOCRINOLOGY

卷:85

Article

Novak, Nicole L.^1,2  Wang, Xu³  Clarke, Philippa J.⁴  Hajat, Anjum⁵  Needham, Belinda L.^1,2  Sanchez, Brisa N.⁶  Rodriguez, Carlos J.⁷  Seeman, Teresa E.⁸  Castro-Diehl, Cecilia^9,10,11  Golden, Sherita Hill^12,13,14  Roux, Ana V. Diez³ 

[1] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, 1415 Washington Hts, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Publ Hlth, Ctr Social Epidemiol & Populat Hlth, 1415 Washington Hts, Ann Arbor, MI 48109 USA

[3] Drexel Univ, Dornsife Sch Publ Hlth, 3215 Market St, Philadelphia, PA 19104 USA

[4] Univ Michigan, Inst Social Res, Survey Res Ctr, 426 S Thompson St, Ann Arbor, MI 48109 USA

[5] Univ Washington, Sch Publ Hlth, Dept Epidemiol, 4225 Roosevelt Way NE,Suite 303, Seattle, WA 98105 USA

[6] Univ Michigan, Sch Publ Hlth, Dept Biostat, SPH 2,Room 4164,1415 Washington Hts, Ann Arbor, MI 48109 USA

[7] Wake Forest Univ, Div Publ Hlth Sci, Sect Cardiol, Dept Epidemiol & Prevent,Sch Med,Dept Internal Me, Med Ctr Blvd, Winston Salem, NC 27157 USA

[8] UCLA, David Geffen Sch Med, Div Geriatr, 10945 Le Conte Ave,Suite 2339, Los Angeles, CA 90095 USA

[9] Columbia Univ Coll Phys & Surg, Dept Med, 630 West 168th St PH9 105, New York, NY 10032 USA

[10] Columbia Univ Coll Phys & Surg, Dept Epidemiol, 630 West 168th St PH9 105, New York, NY 10032 USA

[11] Mailman Sch Publ Hlth, 630 West 168th St PH9 105, New York, NY 10032 USA

[12] Johns Hopkins Univ, Sch Med, Dept Med, 1830 E Monument St,Suite 333, Baltimore, MD 21287 USA

[13] Johns Hopkins Univ, Sch Med, Dept Epidemiol, 1830 E Monument St,Suite 333, Baltimore, MD 21287 USA

[14] Bloomberg Sch Publ Hlth, Div Endocrinol Diabet & Metab, 1830 E Monument St,Suite 333, Baltimore, MD 21287 USA

关键词: Latinos/Hispanics;    Nativity;    Immigrant duration of residence;    Cortisol;    Stress;    Hypothalamic-pituitary-adrenal axis;   

DOI  :  10.1016/j.psyneuen.2017.08.018

来源: Elsevier

【 摘 要 】

Latino immigrants have lower prevalence of depression, obesity and cardiovascular disease than US-born Latinos when they are recently arrived in the US, but this health advantage erodes with increasing duration of US residence. Cumulative exposure to psychosocial stress and its physiological sequelae may mediate the relationship between nativity and duration of US residence and poor health. We used data from Latino cohort study participants ages 45-84 to examine cross-sectional (n = 558) and longitudinal (n = 248) associations between nativity and duration of US residence and features of the diurnal cortisol curve including: wake-up cortisol, cortisol awakening response (CAR, wake-up to 30 min post-awakening), early decline (30 min to 2 h post-awakening) and late decline (2 h post-awakening to bed time), wake-to-bed slope, and area under the curve (AUC). In cross-sectional analyses, US-born Latinos had higher wake-up cortisol than immigrants with fewer than 30 years of US residence. In the full sample, over 5 years the CAR and early decline became flatter and AUC became larger. Over 5 years, US-born Latinos had greater increases in wake-up cortisol and less pronounced flattening of the early diurnal cortisol decline than immigrants with fewer than 30 years of US residence. Immigrants with 30 or more years of US residence also had less pronounced flattening of the early decline relative to more recent immigrants, and also had a less pronounced increase in AUC. In sum, we saw limited cross-sectional evidence that US-born Latinos have more dysregulated cortisol than recently-arrived Latino immigrants, but over time US-born Latinos had slower progression of cortisol dysregulation.

【 授权许可】

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