Structured sparsity regularized multiple kernel learning for Alzheimer's disease diagnosis

PATTERN RECOGNITION

卷:88

Article

Peng, Jialin^1,2,3,4  Zhu, Xiaofeng^3,4  Wang, Ye¹  An, Le^3,4  Shen, Dinggang^3,4,5 

[1] Huaqiao Univ, Coll Comp Sci & Technol, Xiamen, Peoples R China

[2] Huaqiao Univ, Xiamen Key Lab CVPR, Xiamen, Peoples R China

[3] Univ North Carolina Chapel Hill, Dept Radiol, Chapel Hill, NC 27599 USA

[4] Univ North Carolina Chapel Hill, BRIC, Chapel Hill, NC 27599 USA

[5] Korea Univ, Dept Brain & Cognit Engn, Seoul, South Korea

关键词: Structured sparsity;    Multimodal features;    Multiple kernel learning;    Feature selection;    Alzheimer's disease diagnosis;   

DOI  :  10.1016/j.patcog.2018.11.027

来源: Elsevier

【 摘 要 】

Multimodal data fusion has shown great advantages in uncovering information that could be overlooked by using single modality. In this paper, we consider the integration of high-dimensional multi-modality imaging and genetic data for Alzheimer's disease (AD) diagnosis. With a focus on taking advantage of both phenotype and genotype information, a novel structured sparsity, defined by l(1,p)-norm (p > 1), regularized multiple kernel learning method is designed. Specifically, to facilitate structured feature selection and fusion from heterogeneous modalities and also capture feature-wise importance, we represent each feature with a distinct kernel as a basis, followed by grouping the kernels according to modalities. Then, an optimally combined kernel presentation of multimodal features is learned in a data-driven approach. Contrary to the Group Lasso (i.e., l(2, 1)-norm penalty) which performs sparse group selection, the proposed regularizer enforced on kernel weights is to sparsely select concise feature set within each homogenous group and fuse the heterogeneous feature groups by taking advantage of dense norms. We have evaluated our method using data of subjects from Alzheimer's Disease Neuroimaging Initiative (ADNI) database. The effectiveness of the method is demonstrated by the clearly improved prediction diagnosis and also the discovered brain regions and SNPs relevant to AD. (C) 2018 Elsevier Ltd. All rights reserved.

【 授权许可】

Free