An automated pattern recognition system for classifying indirect immunofluorescence images of HEp-2 cells and specimens

PATTERN RECOGNITION

卷:51

Article

Manivannan, Siyamalan¹  Li, Wenqi¹  Akbar, Shazia¹  Wang, Ruixuan¹  Zhang, Jianguo¹  McKenna, Stephen J.¹ 

[1] Univ Dundee, Sch Comp, CVIP, Dundee DD1 4HN, Scotland

关键词: Anti-nuclear antibody test;    Cell classification;    Subcellular fluorescence patterns;    HEp-2 cells;    Multi-resolution local patterns;    Ensemble SVM;   

DOI  :  10.1016/j.patcog.2015.09.015

来源: Elsevier

【 摘 要 】

Immunofluorescence antinuclear antibody tests are important for diagnosis and management of autoimmune conditions; a key step that would benefit from reliable automation is the recognition of subcellular patterns suggestive of different diseases. We present a system to recognize such patterns, at cellular and specimen levels, in images of HEp-2 cells. Ensembles of SVMs were trained to classify cells into six classes based on sparse encoding of texture features with cell pyramids, capturing spatial, multiscale structure. A similar approach was used to classify specimens into seven classes. Software implementations were submitted to an international contest hosted by ICPR 2014 (Performance Evaluation of Indirect Immunofluorescence Image Analysis Systems). Mean class accuracies obtained on heldout test data sets were 87.1% and 88.5% for cell and specimen classification respectively. These were the highest achieved in the competition, suggesting that our methods are state-of-the-art. We provide detailed descriptions and extensive experiments with various features and encoding methods. (C) 2015 The Authors. Published by Elsevier Ltd.

【 授权许可】

Free