Irradiation of Polystyrene and Polypropylene to study NIH 3T3 fibroblasts adhesion

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS

卷:268

Article; Proceedings Paper

del Grosso, M. F.¹  Ibanez, I.¹  Garcia Bermudez, G.¹  Duran, H.¹  Chappa, V. C.¹  Mazzei, R.²  Behar, M.³ 

[1] Consejo Nacl Invest Cient & Tecn, Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina

[2] UTN FRBA, Dpto Ing Quim, CNEA, UA Tecnol & Agropecuarias, Buenos Aires, DF, Argentina

[3] Univ Fed Rio Grande do Sul, Inst Fis, Porto Alegre, RS, Brazil

关键词: Irradiated polymers;    Biocompatibility;    Cell adhesion;   

DOI  :  10.1016/j.nimb.2010.05.041

来源: Elsevier

【 摘 要 】

When polymers are irradiated with heavy ions new chemical groups are created in a few microns of the material. The irradiation changed the polarity and wettability on the surface so that could enhance the biocompatibility of the modified polymer. The study of chemistry and nanoscale topography of the biomaterial is important in determining its potential applications in medicine and biotechnology, because their strong influence on cell function, adhesion and proliferation. In this study, thin films of Polystyrene and Polypropylene samples were modified by irradiation with low energy ion beams (30-150 keV) and swift heavy ions both with various fluences and energies. The changes were evaluated with different methods. Adhesion of NIH 313 fibroblasts onto unirradiated and irradiated surfaces has been studied by in vitro techniques. The correlations between physicochemical properties as a function of different irradiations parameters were compared with cell adhesion on the modified polymer surface. (c) 2010 Elsevier B.V. All rights reserved.

【 授权许可】

Free