Proton transport in water and DNA components: A Geant4 Monte Carlo simulation

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS

卷:306

Article

Champion, C.¹  Incerti, S.¹  Tran, H. N.¹  Karamitros, M.¹  Shin, J. I.²  Lee, S. B.²  Lekadir, H.³  Bernal, M.⁴  Francis, Z.⁵  Ivanchenko, V.⁶  Fojon, O. A.^7,8  Hanssen, J.³  Rivarola, R. D.^7,8 

[1] Univ Bordeaux 1, CNRS IN2P3, CENBG, F-33175 Gradignan, France

[2] Natl Canc Ctr, Proton Therapy Ctr, Goyan, South Korea

[3] Univ Lorraine, Lab Phys Mol & Collis, Nancy, France

[4] Univ Estadual Campinas, Inst Fis Gleb Wataghin, BR-13081970 Campinas, SP, Brazil

[5] Univ St Joseph, Fac Sci, Dept Phys, Beirut, Lebanon

[6] Ecoanalytica, Moscow 119899, Russia

[7] Consejo Nacl Invest Cient & Tecn, Inst Fis Rosario, RA-1033 Buenos Aires, DF, Argentina

[8] Univ Nacl Rosario, RA-2000 Rosario, Santa Fe, Argentina

关键词: Monte Carlo;    Geant4;    Geant4-DNA;    Nucleobases;    Electromagnetic interactions;   

DOI  :  10.1016/j.nimb.2012.12.059

来源: Elsevier

【 摘 要 】

Accurate modeling of DNA damages resulting from ionizing radiation remains a challenge of today's radiobiology research. An original set of physics processes has been recently developed for modeling the detailed transport of protons and neutral hydrogen atoms in liquid water and in DNA nucleobases using the Geant4-DNA extension of the open source Geant4 Monte Carlo simulation toolkit. The theoretical cross sections as well as the mean energy transfers during the different ionizing processes were taken from recent works based on classical as well as quantum mechanical predictions. Furthermore, in order to compare energy deposition patterns in liquid water and DNA material, we here propose a simplified cellular nucleus model made of spherical voxels, each containing randomly oriented nanometer-size cylindrical targets filled with either liquid water or DNA material (DNA nucleobases) both with a density of 1 g/cm(3). These cylindrical volumes have dimensions comparable to genetic material units of mammalian cells, namely, 25 nm (diameter) x 25 nm (height) for chromatin fiber segments, 10 nm (d) x 5 nm (h) for nucleosomes and 2 nm (d) x 2 nm (h) for DNA segments. Frequencies of energy deposition in the cylindrical targets are presented and discussed. (C) 2013 Elsevier B.V. All rights reserved.

【 授权许可】

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