The functional roles of 11β-HSD1:: vascular tissue, testis and brain

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:203

Article

Morris, DJ ; Brem, AS ; Ge, RS ; Jellinck, PH ; Sakai, RR ; Hardy, MP

关键词: GR;    MR;    11 beta-hydroxysteroid dehydrogenase 1 (11 beta-HSD1);    vascular tissues;    testis;    brain;    steroidogenesis;   

DOI  :  10.1016/S0303-7207(03)00094-7

来源: Elsevier

【 摘 要 】

Glucocorticoid hormones bind both glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) exerting a broad spectrum of actions in various tissues. The concentrations of glucocorticoid hormones in the target cells are regulated by 11beta-hydroxysteroid dehydrogenases, type I (11beta-HSD1) and type 2 (11beta-HSD2). 11beta-HSD2 is a unidirectional dehydrogenase, which inactivates biologically active glucocorticoid into inert metabolite, while 11beta-HSD1 is a bi-directional oxidoreductase, which either inactivates biologically active glucocorticoid or activates inert metabolite into active forms. GRs and MRs are present in various tissues and mediate a broad spectrum of physiological actions. The co-existence of 11beta-HSD1 with these two types of receptors plays an important role in regulation of glucocorticoid. actions. This review examines the roles of 11beta-HSD1 in vascular tissues, testis, brain and other tissues such as placental, retinal and adipose tissues. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

【 授权许可】

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