Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:239

Review

Tao, YX

关键词: melanocortin-4 receptor;    melanocortin-3 receptor;    obesity;    mutation;    G protein-coupled receptor;   

DOI  :  10.1016/j.mce.2005.04.012

来源: Elsevier

【 摘 要 】

The neural melanocortin receptors, melanocortin-3 and -4 receptors (MC3R and MC4R), have been shown to regulate different aspects of energy homeostasis in rodents. Human genetic studies showed that mutations in the MC4R gene are the most common monogenic form of obesity. Functional analyses of the mutant receptors revealed multiple defects. A classification scheme is presented for cataloguing the ever-increasing array of MC4R mutations. Functional analysis of the only inactivating MC3R mutation is also summarized. Insights from the analyses of the naturally occurring mutations in the MC3R and MC4R on the structure and function of these receptors are highlighted. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free