Distinct receptor-mediated activities in macrophages for natural ceramide-1-phosphate (C1P) and for phospho-ceramide analogue-1 (PCERA-1)

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:314

Article; Proceedings Paper

Levi, Maya¹  Meijler, Michael M.²  Gomez-Munoz, Antonio³  Zor, Tsaffrir¹ 

[1] Tel Aviv Univ, Inst Life Sci, Dept Biochem, IL-69978 Tel Aviv, Israel

[2] Ben Gurion Univ Negev, Dept Chem, IL-84105 Beer Sheva, Israel

[3] Univ Basque Country, Dept Biochem & Mol Biol, Bilbao 48080, Spain

关键词: Macrophages;    Inflammation;    C1P;    PCERA-1;    Phospholipid-binding receptors;    Cell migration;   

DOI  :  10.1016/j.mce.2009.05.007

来源: Elsevier

【 摘 要 】

Ceramide-1-phosphate (C1P) is known as a second messenger regulating a multitude of processes including cell growth, apoptosis and inflammation. Exciting recent findings now suggest that C1P can stimulate macrophages migration in an extra-cellular manner via a G protein-coupled receptor (GPCR). Interestingly, a synthetic C1P analog, named phospho-ceramide analogue-1 (PCERA-1), was recently described as a potent in-vivo anti-inflammatory agent, and was suggested to act on macrophages in an extra-cellular manner via a GPCR. Here we summarize and compare the receptor-mediated as well as receptor-independent activities of natural C1P and its synthetic analog. We also provide experimental data in support of distinct C1P and PCERA-1 receptors. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free