Neurotransmitter receptors as signaling platforms in anterior pituitary cells

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:463

Article

Zemkova, Hana¹  Stojilkovic, Stanko S.² 

[1] ASCR, Inst Physiol, Dept Cellular & Mol Neuroendocrinol, Prague, Czech Republic

[2] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Sect Cellular Signaling, Bethesda, MD USA

关键词: Pituitary;    Ligand-gated receptor channels;    G protein-coupled receptors;    Neurotransmitters;    Action potentials;    Calcium signaling;    Hormone secretion;   

DOI  :  10.1016/j.mce.2017.07.003

来源: Elsevier

【 摘 要 】

The functions of anterior pituitary cells are controlled by two major groups of hypothalamic and intrapituitary ligands: one exclusively acts on G protein-coupled receptors and the other activates both G protein-coupled receptors and ligand-gated receptor channels. The second group of ligands operates as neurotransmitters in neuronal cells and their receptors are termed as neurotransmitter receptors. Most information about pituitary neurotransmitter receptors was obtained from secretory studies, RT-PCR analyses of mRNA expression and immunohistochemical and biochemical analyses, all of which were performed using a mixed population of pituitary cells. However, recent electrophysiological and imaging experiments have characterized gamma-aminobutyric acid-, acetylcholine-, and ATP-activated receptors and channels in single pituitary cell types, expanding this picture and revealing surprising differences in their expression between subtypes of secretory cells and between native and immortalized pituitary cells. The main focus of this review is on the electrophysiological and pharmacological properties of these receptors and their roles in calcium signaling and calcium-controlled hormone secretion. (C) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

Free