Thyroid hormones and the control of cell proliferation or cell differentiation: Paradox or duality?

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:313

Review

Kress, Elsa¹  Samarut, Jacques¹  Plateroti, Michelina¹ 

[1] Univ Lyon 1, Univ Lyon, Inst Genom Fonct Lyon, Ecole Normale Super Lyon,CNRS,INRA, F-69364 Lyon 07, France

关键词: Thyroid hormones;    Thyroid hormone receptors;   

DOI  :  10.1016/j.mce.2009.08.028

来源: Elsevier

【 摘 要 】

Amphibian metamorphosis perfectly illustrates a key paradox: thyroid hormones control diverse cellular processes depending on the tissue context. This point is also reinforced by a recent accumulation of evidence. For example, thyroid hormones and their nuclear receptor TRs have been described to function in different systems in synergy and/or in antagonism with other signaling pathways. This interaction helps explain their pleiotropic roles. This review summarizes the most important advances in this field, focusing in particular on the key action of thyroid hormones in controlling the balance between the processes of cell proliferation and cell differentiation in a few organs, with special attention paid to the intestine. We highlight similarities between the cellular and molecular events occurring during postnatal intestinal maturation at metamorphosis in amphibians, and comparable events observed at weaning in mice. (C) 2009 Elsevier Ireland Ltd. All rights reserved

【 授权许可】

Free