Interaction between sex hormones and WNT/β-catenin signal transduction in endometrial physiology and disease

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:358

Review

van der Horst, Paul H.¹  Wang, Yongyi¹  van der Zee, Marten¹  Burger, Curt W.¹  Blok, Leen J.¹ 

[1] Erasmus Univ, Med Ctr, Div Gynaecol Oncol, Dept Obstet & Gynaecol, NL-3000 CA Rotterdam, Netherlands

关键词: Wnt/beta-catenin;    Endometrium;    Myometrium;    Mullerian-duct;    Progesterone;    Estrogen;   

DOI  :  10.1016/j.mce.2011.06.010

来源: Elsevier

【 摘 要 】

Wnt/beta-catenin signalling plays a rate-limiting role in early development of many different organs in a broad spectrum of organisms. In the developing Mullerian duct, Wnt/beta-catenin signalling is important for initiation, outgrowth, patterning and differentiation into vagina, cervix, uterus and oviducts. In adult life, sex hormones modulate Wnt/beta-catenin signalling in the endometrium to maintain the monthly balance between estrogen-induced proliferation and progesterone-induced differentiation, and enhanced Wnt/beta-catenin signalling seems to be involved in endometrial carcinogenesis. However, early in pregnancy enhanced Wnt/beta-catenin signalling is prerequisite for proper implantation and invasion of trophoblast cells into endometrium and myometrium thus helping to form a placenta. Overall, it seems that tight control of Wnt/beta-catenin signalling in time and space is important for initiation, development and normal function of the female reproductive tract. However, if Wnt/beta-catenin signalling is not kept in check, it easily seems to initiate or contribute to development of a number of uterine disorders. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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