Lipocalin 2 produces insulin resistance and can be upregulated by glucocorticoids in human adipose tissue

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:427

Article

Kamble, Prasad G.¹  Pereira, Maria J.¹  Sidibeh, Cherno O.¹  Amini, Sam¹  Sundbom, Magnus²  Borjesson, Joey Lau¹  Eriksson, Jan W.¹ 

[1] Uppsala Univ, Dept Med Sci, S-75185 Uppsala, Sweden

[2] Uppsala Univ, Dept Surg, S-75185 Uppsala, Sweden

关键词: Glucocorticoids;    Lipocalin 2;    Human adipose tissue;    Type 2 diabetes;    Insulin resistance;    PPAR gamma;   

DOI  :  10.1016/j.mce.2016.03.011

来源: Elsevier

【 摘 要 】

The adipokine lipocalin 2 is linked to obesity and metabolic disorders. However, its role in human adipose tissue glucose and lipid metabolism is not explored. Here we show that the synthetic glucocorticoid dexamethasone dose-dependently increased lipocalin 2 gene expression in subcutaneous and omental adipose tissue from pre-menopausal females, while it had no effect in post-menopausal females or in males. Subcutaneous adipose tissue from both genders treated with recombinant human lipocalin 2 showed a reduction in protein levels of GLUT1 and GLUT4 and in glucose uptake in isolated adipocytes. In subcutaneous adipose tissue, lipocalin 2 increased IL-6 gene expression whereas expression of PPAR gamma and adiponectin was reduced. Our findings suggest that lipocalin 2 can contribute to insulin resistance in human adipose tissue. In pre-menopausal females, it may partly mediate adverse metabolic effects exerted by glucocorticoid excess. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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