MicroRNAs and the metabolic hallmarks of aging

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:455

Article

Victoria, Berta¹  Lopez, Yury Nunez²  Masternak, Michal M.^1,3 

[1] Univ Cent Florida, Burnett Sch Biomed Sci, Coll Med, 6900 Lake Nona Blvd, Orlando, FL 32827 USA

[2] Florida Hosp, Translat Res Inst Metab & Diabetes, 301 East Princeton St, Orlando, FL 32804 USA

[3] Greater Poland Canc Ctr, Dept Head & Neck Surg, 15 Garbary St, PL-61866 Poznan, Poland

关键词: Aging;    miRNA;    Metabolism;    Microbiome;    Inflammation;    Mitochondria;   

DOI  :  10.1016/j.mce.2016.12.021

来源: Elsevier

【 摘 要 】

Aging, the natural process of growing older, is characterized by a progressive deterioration of physiological homeostasis at the cellular, tissue, and organismal level. Metabolically, the aging process is characterized by extensive changes in body composition, multi-tissue/multi-organ insulin resistance, and physiological declines in multiple signaling pathways including growth hormone, insulin/insulin-like growth factor 1, and sex steroids regulation. With this review, we intend to consolidate published information about microRNAs that regulate critical metabolic processes relevant to aging. In certain occasions we uncover relationships likely relevant to aging, which has not been directly described before, such as the miR-451/AMPK axis. We have also included a provocative section highlighting the potential role in aging of a new designation of miRNAs, namely fecal miRNAs, recently discovered to regulate intestinal microbiota in mammals. (C) 2016 Published by Elsevier Ireland Ltd.

【 授权许可】

Free