Dermatopontin inhibits papillary thyroid cancer cell proliferation through MYC repression

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:480

Article

Guo, Yan^1,2  Li, Hai^1,2  Guan, Hongyu^1,2  Ke, Weijian^1,2  Liang, Weiwei^1,2  Xiao, Haipeng^1,2  Li, Yanbing^1,2 

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, 58 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 1, Diabet Ctr, 58 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China

关键词: Dermatopontin;    Papillary thyroid cancer;    Proliferation;    MYC;    ERK;   

DOI  :  10.1016/j.mce.2018.10.021

来源: Elsevier

【 摘 要 】

Dermatopontin (DPT), a noncollagenous extracellular matrix component, has been illustrated to regulate cellular proliferation and invasiveness in several types of neoplasms. Nevertheless, the biological functions of DPT in cell proliferation, especially papillary thyroid cancer (PTC) cell proliferation, remain unknown, as do the mechanisms underlying its effects. In this study, we detected low DPT expression in PTC, which was related to higher T classifications. Ectopic DPT expression impeded cell proliferation both in vitro and in vivo. Furthermore, we illustrated that DPT down-regulated MYC, which in turn targeted CDK4, CDK6 and p21, through the ERK pathway. These results suggest that DPT regulates CDK4, CDK6 and p21, through MEK-ERK-MYC signaling to repress PTC proliferation.

【 授权许可】

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