The metabolic syndrome, IGF-1, and insulin action

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:299

Article

Arai, Yasumichi¹  Kojima, Toshio²  Takayama, Michiyo¹  Hirose, Nobuyoshi¹ 

[1] Keio Univ, Sch Med, Div Geriatr Med, Dept Internal Med,Shinjuku Ku, Tokyo 1608582, Japan

[2] RIKEN, Genom Sci Ctr, Comparat Syst Biol Team, Yokohama, Kanagawa, Japan

关键词: Aging;    Centenarian;    Insulin/IGF-1 signaling;    Longevity;    Adipokines;    Metabolic syndrome;   

DOI  :  10.1016/j.mce.2008.07.002

来源: Elsevier

【 摘 要 】

Recent studies have shown that insulin and insulin-like growth factor (IGF)-1 signaling are involved in the control of ageing and longevity in model organisms. Based on these studies, genes involved in the insulin/IGF-1 signaling pathway are believed to play a role in longevity throughout evolution and could also be important in determining human longevity. However, human studies have yielded conflicting and controversial results. In human, defects in insulin receptor signaling cause insulin resistance and diabetes, and IGF-1 deficiency is associated with an increased risk of cardiovascular disease and atherosclerosis. Interestingly, insulin sensitivity normally decreases during aging; however. centenarians were reported to maintain greatly increased insulin sensitivity and had a lower prevalence of the metabolic syndrome as compared to younger subjects. Additionally, a longitudinal study revealed that insulin-sensitizing hormones, including leptin and adiponectin, were significantly associated with the survival of centenarians, indicating that an efficient insulin response may influence human longevity. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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