The role of feeding rhythm, adrenal hormones and neuronal inputs in synchronizing daily clock gene rhythms in the liver

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:422

Article

Su, Yan¹  Cailotto, Cathy¹  Foppen, Ewout²  Jansen, Remi¹  Zhang, Zhi²  Buijs, Ruud³  Fliers, Eric²  Kalsbeek, Andries^1,2 

[1] Netherlands Inst Neurosci, Hypothalam Integrat Mech, Meibergdreef 47, NL-1105 BA Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Endocrinol & Metab, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Biol Celulary Fisiol, Mexico City 04510, DF, Mexico

关键词: Circadian;    Feeding;    Adrenalectomy;    Denervation;    Clock genes;    Liver;   

DOI  :  10.1016/j.mce.2015.12.011

来源: Elsevier

【 摘 要 】

The master clock in the hypothalamic suprachiasmatic nucleus (SCN) is assumed to distribute rhythmic information to the periphery via neural, humoral and/or behavioral connections. Until now, feeding, corticosterone and neural inputs are considered important signals for synchronizing daily rhythms in the liver. In this study, we investigated the necessity of neural inputs as well as of the feeding and adrenal hormone rhythms for maintaining daily hepatic clock gene rhythms. Clock genes kept their daily rhythm when only one of these three signals was disrupted, or when we disrupted hepatic neuronal inputs together with the adrenal hormone rhythm or with the daily feeding rhythm. However, all clock genes studied lost their daily expression rhythm after simultaneous disruption of the feeding and adrenal hormone rhythm. These data indicate that either a daily rhythm of feeding or adrenal hormones should be present to synchronize clock gene rhythms in the liver with the SCN. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free