Gut feelings about bacterial steroid-17,20-desmolase

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:525

Article

Ly, Lindsey K.^1,2,3  Doden, Heidi L.^1,3  Ridlon, Jason M.^1,2,3,4,5 

[1] Carl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA

[2] Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA

[3] Univ Illinois, Dept Anim Sci, Urbana, IL USA

[4] Univ Illinois, Canc Ctr Illinois, Urbana, IL USA

[5] Virginia Commonwealth Univ, Dept Microbiol & Immunol, Sch Med, Richmond, VA USA

关键词: Glucocorticoid;    Cortisol;    Microbiome;    Steroid-17,20-desmolase;    11-Oxy-androgen;    Hydroxysteroid dehydrogenase;    Sterolbiome;    GALF;   

DOI  :  10.1016/j.mce.2021.111174

来源: Elsevier

【 摘 要 】

Advances in technology are only beginning to reveal the complex interactions between hosts and their resident microbiota that have co-evolved over centuries. In this review, we present compelling evidence that implicates the host-associated microbiome in the generation of 11 beta-hydroxyandrostenedione, leading to the formation of potent 11-oxy-androgens. Microbial steroid-17,20-desmolase cleaves the side-chain of glucocorticoids (GC), including cortisol (and its derivatives of cortisone, 5 alpha-dihydrocortisol, and also (allo)- 3 alpha, 5 alpha-tetrahydrocortisol, but not 3 alpha-5 beta-tetrahydrocortisol) and drugs (prednisone and dexamethasone). In addition to side-chain cleavage, we discuss the gut microbiome's robust potential to transform a myriad of steroids, mirroring much of the host's metabolism. We also explore the overlooked role of intestinal steroidogenesis and efflux pumps as a potential route for GC transport into the gut. Lastly, we propose several health implications from microbial steroid-17,20-desmolase function, including aberrant mineralocorticoid, GC, and androgen receptor signaling in colonocytes, immune cells, and prostate cells, which may exacerbate disease states.

【 授权许可】

Free