TUMOR-NECROSIS-FACTOR-ALPHA AND INTERFERON-GAMMA INHIBIT INSULIN-LIKE GROWTH FACTOR-II GENE-EXPRESSION IN HUMAN FETAL ADRENAL-CELL CULTURES

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:91

Article

ILVESMAKI, V ; JAATTELA, M ; SAKSELA, E ; VOUTILAINEN, R

关键词: TUMOR NECROSIS FACTOR;    INTERFERON;    INSULIN-LIKE GROWTH FACTOR;    ADRENAL;   

DOI  :  10.1016/0303-7207(93)90255-I

来源: Elsevier

【 摘 要 】

Insulin-like growth factor-II (IGF-II) gene expression is induced by adrenocorticotropic hormone (ACTH) in human fetal adrenals (HFA), which suggests an important role for IGF-II in HFA growth and differentiation. Many cytokines have different regulatory actions in the endocrine glands. In the present study we have investigated the effects of two cytokines, tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), on the regulation of IGF-II gene expression in cultured HFA cells. Both TNF-alpha and IFN-gamma inhibited basal and ACTH-induced accumulation of IGF-II mRNA dose-dependently. Cell viability was not altered by treatment with TNF-alpha or IFN-gamma. In addition, the combination of TNF-alpha and IFN-gamma decreased ACTH-induced IGF-II mRNAs more potently than each cytokine alone. Our results suggest that TNF-alpha and IFN-gamma may be involved in the regulation of HFA growth and differentiation via local IGF-II production.

【 授权许可】

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