The pathway to femaleness: current knowledge on embryonic development of the ovary

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:230

Article

Yao, HHC

关键词: sex determination;    gonad;    ovary;    follicle;    germ cells;    oocyte;    estrogen;    follistatin;    Fig alpha;    Foxl2;    Wnt4;   

DOI  :  10.1016/j.mce.2004.11.003

来源: Elsevier

【 摘 要 】

Increasing evidence indicates that organogenesis of the ovary is not a passive process arising by default in the absence of the testis pathway. A coordinated interaction is actually in force between somatic cells and female germ cells in embryonic ovaries, thus creating a unique microenvironment that facilitates the formation of follicles. Identification of the functional roles of several novel regulatory elements such as Figalpha, Fox12, follistatin, and Wnt4 reveals the complexity of early ovarian organization. Challenges await us to establish the molecular connections of these molecules as well as to discover new candidates in the pathway of early ovarian development. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free