Inflammatory pathways in endometrial disorders

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:335

Review

Maybin, Jacqueline A.²  Critchley, Hilary O. D.²  Jabbour, Henry N.¹ 

[1] Queens Med Res Inst, MRC Human Reprod Sci Unit, Edinburgh EH16 4TJ, Midlothian, Scotland

[2] Univ Edinburgh, Ctr Reprod Biol, Queens Med Res Inst, Edinburgh EH16 4TJ, Midlothian, Scotland

关键词: Menstruation;    Implantation;    Fibroids;    Endometriosis;    Menorrhagia;    Prostaglandins;    Hypoxia;   

DOI  :  10.1016/j.mce.2010.08.006

来源: Elsevier

【 摘 要 】

Complex interactions between the endocrine and immune systems govern the key endometrial events of implantation and menstruation. In contrast to other tissue sites, cyclical endometrial inflammation is physiological. However, dysregulation of this inflammatory response can lead to endometrial disorders. This review examines the inflammatory processes occurring in the normal endometrium during menstruation and implantation, highlighting recent advances in our understanding and gaps in current knowledge. Subsequently, the role of inflammatory pathways in the pathology of various common endometrial conditions is discussed, including heavy menstrual bleeding, dysmenorrhoea (painful periods), uterine fibroids, endometriosis and recurrent miscarriage. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free