Sheep models of polycystic ovary syndrome phenotype

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:373

Review

Padmanabhan, Vasantha¹  Veiga-Lopez, Almudena² 

[1] Univ Michigan, Dept Pediat, Dept Obstet & Gynecol, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA

关键词: Infertility;    PCOS;    Fetal programming;    Androgens;    Oestrogens;   

DOI  :  10.1016/j.mce.2012.10.005

来源: Elsevier

【 摘 要 】

Polycystic ovary syndrome (PCOS) is a fertility disorder affecting 5-7% of reproductive-aged women. Women with PCOS manifest both reproductive and metabolic defects. Several animal models have evolved, which implicate excess steroid exposure during fetal life in the development of the PCOS phenotype. This review addresses the fetal and adult reproductive and metabolic consequences of prenatal steroid excess in sheep and the translational relevance of these findings to PCOS. By comparing findings in various breeds of sheep, the review targets the role of genetic susceptibility to fetal insults. Disruptions induced by prenatal testosterone excess are evident at both the reproductive and metabolic level with each influencing the other thus creating a self-perpetuating vicious cycle. The review highlights the need for identifying a common mediator of the dysfunctions at the reproductive and metabolic levels and developing prevention and treatment interventions targeting all sites of disruption in unison for achieving optimal success. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free